Search results for "Fibrolast growth factor receptor-1"

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Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis

2006

The aim of the study was to investigate the expression of basic fibroblast growth factor (bFGF) and its receptor, fibroblast growth factor receptor (FGFR)-1, in the central airways of smokers with chronic bronchitis. The lobar bronchi from 17 subjects undergoing thoracotomy for solitary nodules were examined. All had a history of cigarette smoking, nine had symptoms of chronic bronchitis and airflow limitation, and eight were asymptomatic with normal lung function. Using immunohistochemical methods, bFGF and FGFR-1 expression in the total airway wall and the different airway compartments, i.e. bronchial glands, submucosal vessels and smooth muscle, was quantified. Moreover, to investigate t…

MalePulmonary and Respiratory MedicinePathologymedicine.medical_specialtyChronic bronchitisAngiogenesisBasic fibroblast growth factorFibroblast growth factorchemistry.chemical_compoundGrowth factor receptorCigarette smokingHumansMedicineAgedFibrolast growth factor receptor-1business.industryChronic obstructive pulmonary diseaseFibroblast growth factor receptor 1Smokingrespiratory systemmedicine.diseaseAirway remodelling; cigarette smoking; chronic obstructive pulmonary disease; fibroblast growth factor receptor-1Airway remodellingUp-Regulationrespiratory tract diseasesBronchitis ChronicchemistryFibroblast growth factor receptorBronchitisFemaleFibroblast Growth Factor 2Airway remodelling; Chronic obstructive pulmonary disease; Cigarette smoking; Fibrolast growth factor receptor-1;business
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